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pentobarbital will lower the level or result of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Avoid coadministration of lefamulin with sturdy or moderate CYP3A inducers Except if the benefit outweighs risks. Keep an eye on for minimized efficacy.pentobarbital will lessen the level or outcom